April 1, 1999Molecular Biology of the CellOpen Access

The Tail of a Yeast Class V Myosin, Myo2p, Functions as a Localization Domain

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Population

Saccharomyces cerevisiae (yeast) strains (wild-type and MYO2DN)

Comparison

Overexpression of the carboxyl-terminal-tail… vs Yeast cells transformed with the GAL1 vector alone

Design

Preclinical

Authors

SRSamara L. Reck‐PetersonHoward Hughes Medical Institute PNPeter NovickUniversity of California, San Diego MMMark S. MoosekerHeart Failure / Cardiomyopathy

Discussion

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Implication

Yeast myosin findings offer no immediate clinical implications; leaves open extension to mammalian cardiovascular cell biology.

Structured PICO

Population

Saccharomyces cerevisiae (yeast) strains (wild-type and MYO2DN)

Intervention

Overexpression of the carboxyl-terminal-tail domain of Myo2p behind the regulatable GAL1 promoter

Comparator

Yeast cells transformed with the GAL1 vector alone (wild-type)

Outcome

Localization of Myo2p and phenotypic effects (growth, budding, vesicle accumulation)

The carboxyl-terminal tail of the yeast class V myosin Myo2p is sufficient for localization to sites of polarized cell growth and its overexpression competitively inhibits endogenous Myo2p localization.

Cite This Study

Reck‐Peterson et al. (1999) studied this question.

synapsesocial.com/papers/6a7b735e1ba4614d7ff4377f https://doi.org/10.1091/mbc.10.4.1001

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The Tail of a Yeast Class V Myosin, Myo2p, Functions as a Localization Domain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Tail of a Yeast Class V Myosin, Myo2p, Functions as a Localization Domain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider