Key result
In Saccharomyces cerevisiae, the bud cortex signals successful vacuole delivery, leading to Cla4-dependent phosphorylation and degradation of Vac17 to release the vacuole from Myo2.
The study identifies that Cla4-dependent phosphorylation of Vac17 at the bud cortex is a critical spatial signal for vacuole release from myosin V in yeast.
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No immediate clinical implications; leaves open conservation of organelle release mechanisms in mammalian cells.
Yau et al. (2017) studied this question. In Saccharomyces cerevisiae, the bud cortex signals successful vacuole delivery, leading to Cla4-dependent phosphorylation and degradation of Vac17 to release the vacuole from Myo2.
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