Key result
Cargo adaptors Vac17 and Inp2 bind Myo2 at multiple sites supporting handhold organelle transport in yeast.
Cargo adaptors use a 'handhold' mechanism involving multiple binding sites to engage with myosin V for organelle transport in budding yeast.
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No immediate clinical relevance; extends yeast myosin-cargo model but leaves open conservation in mammalian cells.
Hahn et al. (2025) studied Organelle transport in budding yeast. Cargo adaptors Vac17 and Inp2 interact with the Myo2 motor at multiple distinct sites, supporting a handhold model for organelle transport in budding yeast.
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