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April 10, 2026Ophthalmic and Physiological Optics2 citationsOpen Access

Negligible Rebound in Myopia Progression Following Cessation of Treatment with 0.01% Atropine for 3 years: Year-4 Results from the CHAMP Phase 3 Clinical Trial

KZKarla ZadnikESErica SchulmanIFIan Flitcroft

Key Points

  • This research aims to assess the rebound effect on myopia progression after stopping 0.01% atropine treatment for three years.
  • Conducted as part of the CHAMP clinical trial.
  • Participants received 0.01% atropine for myopia control.
  • Myopia progression was monitored for four years, including one year post-treatment.
  • Minimal rebound in myopia progression observed after stopping treatment.
  • Results demonstrate sustained efficacy of 0.01% atropine for myopia control over three years.

Abstract

The Childhood Atropine for Myopia Progression (CHAMP) study was registered in clinicaltrials.gov (NCT03350620, registration date November 17, 2017).

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Cite This Study

Zadnik et al. (2026) studied this question.

synapsesocial.com/papers/69d896046c1944d70ce07421https://doi.org/10.1007/s44402-026-00064-w
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