What question did this study set out to answer?

The research aims to explore the neuroprotective effects of Beta vulgaris extract and betanin on autism-like behaviors and related molecular alterations in a rat model.

April 10, 2026Bratislavské lekárske listy/Bratislava medical journalOpen Access

Red Beet (Beta vulgaris) Extract and Betanin Attenuate Valproic Acid–Induced Autism-Like Neurobehavioral and Molecular Alterations via Modulation of Oxidative Stress, Neuroinflammation, Apoptosis, and Reelin Signaling

View Full Paper

Ask AI

Bookmark

Authors

NANada S. Al-wakeelAin Shams University MSManar E. SelimAndalas University YAYasmina M. Abd-ElhakimZagazig University

Discussion

Member takes

Implication

Demonstrates neuroprotective effects of Beta vulgaris extract and betanin in a rat model of autism-induced behaviors, suggesting potential alternative treatments.

Key Points

The research aims to explore the neuroprotective effects of Beta vulgaris extract and betanin on autism-like behaviors and related molecular alterations in a rat model.
Used a rat model exposed to valproic acid (VPA) prenatally to induce autism-like symptoms.
Postnatal treatment involved administering either water, extract solvent, Beta vulgaris extract, or betanin.
Behavioral assessments measured sociability and social novelty during the treatment period from postnatal day 23 to 37.
Biochemical analyses evaluated oxidative stress markers, neurotransmitter levels, apoptotic markers, and gene expression in brain tissue.
Beta vulgaris extract and betanin significantly improved sociability and social novelty in the VPA-exposed rats.
Treatment with extract and betanin enhanced GABA levels while reducing oxidative stress markers like MDA.
Both treatments elevated antioxidant defenses (GSH and CAT) and decreased pro-inflammatory cytokines (TNF-alpha).
Apoptotic markers were normalized and brain histopathological abnormalities were improved following treatments.
Reelin gene expression, which was suppressed by VPA, significantly upregulated post-treatment.

Cite This Study

Al-wakeel et al. (2026) studied this question.

synapsesocial.com/papers/69d896406c1944d70ce07992 https://doi.org/10.1007/s44411-026-00579-1

View Full Paper

Ask AI

Bookmark

Implication

Demonstrates neuroprotective effects of Beta vulgaris extract and betanin in a rat model of autism-induced behaviors, suggesting potential alternative treatments.

Red Beet (Beta vulgaris) Extract and Betanin Attenuate Valproic Acid–Induced Autism-Like Neurobehavioral and Molecular Alterations via Modulation of Oxidative Stress, Neuroinflammation, Apoptosis, and Reelin Signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

Red Beet (Beta vulgaris) Extract and Betanin Attenuate Valproic Acid–Induced Autism-Like Neurobehavioral and Molecular Alterations via Modulation of Oxidative Stress, Neuroinflammation, Apoptosis, and Reelin Signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider