Key result
Adiponectin/leptin ratio inversely correlates with VAT, systemic insulin resistance, and inflammation in postmenopausal females.
Why the study?
The role of the adiponectin/leptin ratio in visceral adipose tissue accumulation and the impact of sex on these associations had not been evaluated.
Does the adiponectin/leptin ratio (ALR) associate with visceral adipose tissue accumulation and metabolic damage in a sex-specific manner?
Cross-Sectional (n=54)
Does the adiponectin/leptin ratio (ALR) associate with visceral adipose tissue accumulation and metabolic damage in a sex-specific manner?
The adiponectin/leptin ratio is a sex-specific biomarker associated with visceral adipose tissue accumulation and metabolic dysfunction, highlighting its potential utility in metabolic disease risk assessment.
May aid sex-specific ALR assessment of VAT-metabolic risk; extends its role as adipose dysfunction biomarker but hypothesis-generating.
Adipose tissue (AT) dysfunction can lead to increased visceral AT (VAT) and metabolic damage. The adiponectin/leptin ratio (ALR) has been proposed as a biomarker of AT functionality. However, its participation in VAT accumulation and the impact of sex on these associations have not been evaluated. In an analytical cross-sectional study, 54 adults (29 male, 25 postmenopausal females, aged 30-70 years, BMI 19-31 kg/m²) were analysed. Anthropometric data, fasting serum samples, and subcutaneous AT (SAT) biopsies were obtained. Morpho-functional AT characteristics included ALR, adipocyte size, macrophage content and AT insulin resistance (ADIPO-IR). Using multivariate and mediation models, we evaluated the associations of SAT characteristics with systemic IR (TyG index), systemic inflammation (C-reactive protein), and VAT area. In postmenopausal females, ALR was inversely associated with adipocyte size, macrophage number, TyG index, CRP, and VAT area. SAT inflammation and ADIPO-IR were independently associated with VAT, and a mediation model suggested ALR as a possible precursor of VAT. Among males, ADIPO-IR and ALR were independently associated with VAT. These findings emphasize the importance of considering sex differences in the prevention and treatment strategies for metabolic diseases among Mexican-Mestizo populations, although these results should be confirmed by prospective studies.
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Medina-Urrutia et al. (2026) conducted a cross-sectional in Adiposopathy and visceral adipose tissue accumulation (n=54). Adiponectin/leptin ratio (ALR) was evaluated on Associations of subcutaneous adipose tissue characteristics with systemic insulin resistance, systemic inflammation, and visceral adipose tissue area. The adiponectin/leptin ratio was inversely associated with visceral adipose tissue area, systemic insulin resistance, and inflammation in postmenopausal females.
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