Retrospective cohort study identifies molecular and histopathological factors affecting survival in mucosal melanoma, indicating a need for improved diagnostics.
Key Points
To evaluate histopathological and molecular parameters that influence survival in patients with mucosal melanoma.
Conducted a retrospective study on 51 patients with mucosal melanoma from 2016 to 2024.
Assessed histopathological characteristics by experienced pathologists.
Retrieved molecular data from next-generation sequencing targeting common oncogenic drivers.
Correlated molecular and histopathological findings with clinical data and survival outcomes.
Proliferative activity and residual in situ disease were found to have prognostic relevance.
Disease-free survival was significantly impacted by M1 status, ulceration, and high mitotic activity on univariate analysis.
Overall survival decreased in cases with M1 status and residual in situ component in both analytical models.
NRAS was the most prevalent mutation, but no significant survival association was found.