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April 10, 2026HLA2 citations

Identification of the Novel HLA‐A*02:1040:02 Allele by Next‐Generation Sequencing

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ZDZeying DuMayo Clinic in FloridaMSMa. Easter April SudarioMayo Clinic in FloridaANAubrey E. NicksMayo Clinic in Florida

Key Points

  • The research aims to identify and characterize the HLA-A*02:1040:02 allele through advanced sequencing methods.
  • Utilized next-generation sequencing for precise genetic analysis.
  • Focused on the nucleotide substitutions in HLA gene alleles.
  • Analyzed differences at codon 283 in exon 5.
  • Identified HLA-A*02:1040:02 as distinct from HLA-A*02:01:01:01.
  • Confirmed the difference is due to a single nucleotide change (CCC>TCC).

Abstract

HLA-A*02:1040:02 differs from HLA-A*02:01:01:01 by a single nucleotide substitution in codon 283 (CCC>TCC) in exon 5.

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Cite This Study

Du et al. (2026) studied this question.

synapsesocial.com/papers/69d8970c6c1944d70ce084aahttps://doi.org/10.1111/tan.70704
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