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December 5, 2025HLA

Identification of the Novel HLA‐A*02:540:02N Allele by Next‐Generation Sequencing

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Authors

CBCharlène BouthemyJMJean MilhèsMFMarylise Fort

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Implication

Novel HLA-A*02:540:02N allele identified by nucleotide substitution in codon 99, suggesting unique genetic characteristics.

Key Points

  • HLA-A*02:540:02N was identified through next-generation sequencing, revealing a unique genetic variant.
  • The allele differs from HLA-A*02:01:01:01 by a single nucleotide change located in codon 99.
  • Analysis focuses on exon 3 where the substitution occurs, emphasizing its significance in genetic diversity.
  • Understanding this allele is important for population genetics and potential implications in transplantation.

Cite This Study

Bouthemy et al. (2025) studied this question.

synapsesocial.com/papers/6932311e8e51979591dce472https://doi.org/10.1111/tan.70499
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