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April 10, 2026Cornea

Recurrence Rate After Phototherapeutic Keratectomy in Epithelial–Stromal TGFBI Corneal Dystrophies Compared With Epithelial Basement Membrane Dystrophy

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Authors

TPTommaso PaolettiLDLoay DaasCMCristian Munteanu

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Overview

Retrospective study compares recurrence rates of TGFBI corneal dystrophies and EBMD post-PTK, highlighting significant differences.

Key Points

  • This study aims to compare recurrence rates and functional outcomes post-PTK in TGFBI corneal dystrophies versus EBMD.
  • Single-center retrospective comparative study
  • Analyzed recurrence rates after excimer laser PTK
  • Included 63 eyes with TGFBI dystrophies and 163 eyes with EBMD
  • Conducted Kaplan-Meier survival analysis
  • Utilized two-way ANOVA for data analysis
  • Recurrence rate in the TGFBI group was 52% with a mean time to recurrence of 3.0 ± 2.8 years
  • Only 1.2% of EBMD eyes required a second PTK due to significant recurrence
  • No significant differences in recurrence among TGFBI dystrophies, likely due to limited sample size
  • PTK demonstrated functional and symptomatic improvements, especially in EBMD

Cite This Study

Paoletti et al. (2026) studied this question.

synapsesocial.com/papers/69d8970c6c1944d70ce0852fhttps://doi.org/10.1097/ico.0000000000004157
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phototherapeutic Keratectomy for epithelial basement membrane dystrophy: long-term observation in Chinese patients2026
  2. 2Phototherapeutic Keratectomy: Science and Art2017 · 49 citations
  3. 3Photorefractive keratectomy with extended ablation zone for recurrent corneal erosion syndrome accompanied with refractive errors: a study of effectiveness, safety, and refractive outcomes2025
  4. 4Phototherapeutic Keratectomy Results for the Treatment of Corneal Scarring After Pterygium Excision2024
  5. 5Comparison of Preoperative Refractive Status and Postoperative Outcomes Following Transepithelial Photorefractive Keratectomy2026