December 15, 2016Science ImmunologyOpen Access

Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors

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Population

Memory B cells from 3 healthy adult donors naturally infected with RSV

Design

Preclinical

Authors

MGMorgan S. A. GilmanBoston University CCCarlos A. CastellanosThe Francis Crick Institute MCMan ChenShandong Provincial Hospital

Discussion

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Implication

No immediate change to RSV prevention; leaves open new targets for human vaccine and mAb development.

Structured PICO

Population

Memory B cells from 3 healthy adult donors naturally infected with RSV

Intervention

Isolation and characterization of 364 RSV F-specific monoclonal antibodies

Outcome

Specificities and functional activities of RSV F-specific antibodiessurrogate

Identification of highly potent RSV F-specific antibodies targeting a novel preF apex site provides new targets for RSV vaccine design and passive prophylaxis.

Cite This Study

Gilman et al. (2016) studied this question.

synapsesocial.com/papers/69d89b76de3177251abedbbc https://doi.org/10.1126/sciimmunol.aaj1879

View Full Paper

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Bookmark

Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider