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March 25, 2014Proceedings of the National Academy of SciencesOpen Access

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

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Authors

AMAndrew MurphyGeneral CardiologyLMLynn E. MacdonaldRegeneron (United States)SSSean StevensAustin Health

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Murphy et al. (2014) studied this question.

synapsesocial.com/papers/69d8a4c1945c639271bed8cahttps://doi.org/10.1073/pnas.1324022111
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  1. 1A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.1989 · 151 citations
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  4. 4A humanized antibody that binds to the interleukin 2 receptor.1989 · 630 citations