Incidence and Risk of Dementia: The Rotterdam study
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Discussion
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Implication
Prospective cohort study reveals a lifetime dementia risk of 33% in women versus 16% in men, highlighting the substantial impact of longer female life expectancy on disease burden.
Key Points
- To assess age-, sex-, and subtype-specific incidence rates of dementia and determine the lifetime cumulative risk of developing dementia among older adults.
- Prospective community-based cohort study of 7,046 nondemented participants aged 55 years and older evaluated at baseline between 1990 and 1993.
- Participants underwent a three-stage dementia screening protocol and medical record surveillance over an average follow-up of 2.1 years (15,135 person-years).
- Cumulative dementia risk was calculated across age and sex categories using incidence rates and dementia-free Kaplan-Meier survival tables.
- Overall dementia incidence was 10.7 per 1,000 person-years (162 cases), climbing steadily from 0.6 in the youngest 5-year age bracket to 97.2 per 1,000 person-years in the oldest bracket, plateauing after age 85 only in men.
- By subtype, incidence per 1,000 person-years was 7.7 for Alzheimer's disease and 1.5 for vascular dementia.
- Lifetime risk of dementia at age 55 was 0.33 for women compared to 0.16 for men, despite similar incidence rates between sexes up to age 85.
Cite This Study
Ott et al. (1998) studied this question.