What question did this study set out to answer?

To evaluate the infectivity, clinical consequences, and minimal infectious dose of small-particle aerosolized A2 influenza virus in human volunteers.

July 1, 1966Experimental Biology and Medicine

Human Influenza Resulting from Aerosol Inhalation

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Authors

RARobert H. AlfordSaint Thomas West Hospital JKJ. A. KaselAustralian National University PGPeter J. GeroneTulane University

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Implication

Human challenge trial demonstrates low-dose aerosol transmission of A2 influenza in volunteers, suggesting airborne particles cause illness despite low neutralizing antibody levels.

Key Points

To evaluate the infectivity, clinical consequences, and minimal infectious dose of small-particle aerosolized A2 influenza virus in human volunteers.
Administered small-particle aerosols containing A2 influenza virus to human volunteers.
Assessed infection, clinical illness, and baseline serum neutralizing antibody titers in exposed subjects.
Small-particle aerosol delivery of low virus doses successfully produced infection and typical influenza symptoms.
Low levels of preexisting serum neutralizing antibody failed to provide complete protection against infection and illness.
The minimum human infectious dose for aerosolized virus in antibody-free subjects was approximately 3 TCID50.

Cite This Study

Alford et al. (1966) studied this question.

synapsesocial.com/papers/69d8b87133ca018b39ae3e63 https://doi.org/10.3181/00379727-122-31255

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Implication

Human challenge trial demonstrates low-dose aerosol transmission of A2 influenza in volunteers, suggesting airborne particles cause illness despite low neutralizing antibody levels.

Human Influenza Resulting from Aerosol Inhalation

Discussion

Member takes

Implication

Key Points

Cite This Study

Human Influenza Resulting from Aerosol Inhalation

Discussion

Member takes

Implication

Key Points

Cite This Study

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