Activation of the Bone Morphogenetic Protein Receptor by H11Kinase/Hsp22 Promotes Cardiac Cell Growth and Survival

Transgenic mouse model with cardiac-specific overexpression of H11K and isolated cardiac myocytes

H11K overexpression (transgenic mice and adenovirus-mediated in isolated myocytes)

Wild-type mice and control isolated myocytes

Activation of the BMP signaling pathway and PI3K/Akt pathway (measured by receptor upregulation, Smad 1/5/8 phosphorylation, PI3K activity, phospho-Akt, and apoptosis reduction)surrogate