Why the study?
Does proteasome inhibition with epoxomicin improve cardiac remodeling and function in mice with pressure overload-induced hypertrophy?
Does proteasome inhibition with epoxomicin improve cardiac remodeling and function in mice with pressure overload-induced hypertrophy?
Proteasome inhibition with epoxomicin rescues ventricular remodeling and stabilizes cardiac function in a mouse model of pressure overload.
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Epoxomicin may attenuate remodeling in pressure-overload models; hypothesis-generating and requires clinical validation.
Hedhli et al. (2008) studied this question.
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