Why the study?
Does etomoxir improve cardiac function and prevent subcellular remodeling in rats with pressure overload-induced cardiac hypertrophy?
Population
Rats with cardiac hypertrophy induced by abdominal aorta banding (pressure overload) for 8 weeks
Comparison
Etomoxir (inhibitor of palmitoyltransferase-1) vs Sham-operated animals and untreated…
Design
Preclinical
Follow-up
8 weeks
Authors
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Etomoxir merits further preclinical study in hypertrophy models; leaves open any role in human heart failure.
Does etomoxir improve cardiac function and prevent subcellular remodeling in rats with pressure overload-induced cardiac hypertrophy?
Modifying myocardial metabolism with etomoxir may prevent subcellular remodeling and improve cardiac function in pressure overload-induced hypertrophy.
Dhalla et al. (1999) studied this question.
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