Why the study?
Does etomoxir improve left ventricular performance in a rat model of pressure-overload cardiac hypertrophy?
Population
Sham-operated rats and rats with ascending aorta constriction (pressure-overloaded hypertrophied heart model)
Comparison
Racemic etomoxir (15 mg/kg per day) for 12 weeks vs Untreated rats
Design
Preclinical
Follow-up
12 weeks
Authors
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Etomoxir improves LV performance in rat pressure-overload hypertrophy; leaves open translation to human HF therapy.
Does etomoxir improve left ventricular performance in a rat model of pressure-overload cardiac hypertrophy?
Long-term treatment with the carnitine palmitoyltransferase-1 inhibitor etomoxir improves functional capacity and myocardial performance in pressure-overloaded rat hearts.
Turčáni et al. (1997) studied this question.
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