Why the study?
Does etomoxir prevent changes in sarcoplasmic reticulum gene expression in rats with pressure overload cardiac hypertrophy?
Population
Rats with pressure overload cardiac hypertrophy induced by 8 weeks of aortic constriction
Comparison
Etomoxir vs Untreated rats with pressure overload
Design
Preclinical
Follow-up
8 weeks
Authors
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Etomoxir may preserve sarcoplasmic reticulum gene expression in rat pressure-overload hypertrophy; hypothesis-generating and leaves open clinical translation.
Does etomoxir prevent changes in sarcoplasmic reticulum gene expression in rats with pressure overload cardiac hypertrophy?
Etomoxir preserves sarcoplasmic reticulum gene expression in pressure-overloaded hypertrophied hearts, suggesting a potential therapeutic approach to prevent the transition from hypertrophy to heart failure.
Zarain‐Herzberg et al. (1996) studied this question.
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