Why the study?
Does etomoxir alter cardiac sarcoplasmic reticulum Ca2+ transport in normotensive rats?
Does etomoxir alter cardiac sarcoplasmic reticulum Ca2+ transport in normotensive rats?
CPT-1 inhibition by etomoxir has a chamber-specific effect on cardiac sarcoplasmic reticulum Ca2+ transport and isomyosins, with more pronounced effects in the left ventricle.
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Chamber-specific Ca2+ effects in normotensive rats do not inform practice; leaves open CPT-1 inhibition in human disease models.
Vetter et al. (1994) studied this question.
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