Why the study?
Does etomoxir improve sarcoplasmic reticulum Ca2+ uptake and prevent heart failure progression in rats with severe left ventricular pressure overload?
Does etomoxir improve sarcoplasmic reticulum Ca2+ uptake and prevent heart failure progression in rats with severe left ventricular pressure overload?
In a rat model of pressure overload-induced heart failure, carnitine palmitoyltransferase-1 inhibition with etomoxir improved sarcoplasmic reticulum calcium uptake and reduced right ventricular hypertrophy.
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Etomoxir-linked gains in SR Ca2+ uptake and reduced RV hypertrophy in rats should not yet change practice; leaves open CPT-1 inhibition efficacy in human pressure-overload HF.
Rupp et al. (2000) studied this question.
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