Why the study?
Does etomoxir modify subcellular organelles and cardiac growth in pressure-overloaded rat hearts?
Population
Rats with cardiac hypertrophy induced by constriction of the abdominal aorta
Comparison
Etomoxir 12-15 mg/kg body wt for 12-13 weeks vs Pressure overload alone
Design
Preclinical
Follow-up
12-13 weeks
Authors
Loading...
CPT-1 inhibition may dissociate hypertrophy from molecular remodeling in pressure overload; leaves open effects on human HF progression.
Does etomoxir modify subcellular organelles and cardiac growth in pressure-overloaded rat hearts?
A shift in myocardial substrate utilization via CPT-1 inhibition with etomoxir dissociates cardiac muscle growth from changes in subcellular organelles, preventing molecular remodeling in pressure overload.
Rupp et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: