Does gp130 activation promote cardiomyocyte proliferation and heart regeneration?
Activation of gp130 promotes cardiomyocyte proliferation via the Src-Yap pathway, suggesting it as a potential therapeutic target for heart regeneration after cardiac injury.
Macrophage recruitment is essential for heart regeneration through the secretion of OSM, which promotes cardiomyocyte proliferation. As the coreceptor of OSM, gp130 activation is sufficient to promote cardiomyocyte proliferation by activating Yap through Src during heart regeneration. gp130 is a potential therapeutic target to improve heart regeneration after cardiac injury.
Li et al. (Tue,) studied this question.