Key result
gp130 activation promotes cardiomyocyte proliferation and cardiac regeneration via Src-mediated Yap activation after injury.
Why the study?
The mechanisms by which gp130 activation promotes cardiomyocyte proliferation and heart regeneration after cardiac injury are not fully understood.
Does gp130 activation promote cardiomyocyte proliferation and heart regeneration?
Does gp130 activation promote cardiomyocyte proliferation and heart regeneration?
Activation of gp130 promotes cardiomyocyte proliferation via the Src-Yap pathway, suggesting it as a potential therapeutic target for heart regeneration after cardiac injury.
No takes yet. Share an insight, caveat, or question.
May identify gp130 as a regenerative target; hypothesis-generating in animals and requires human validation.
Li et al. (2020) studied this question. gp130 activation promotes cardiomyocyte proliferation and heart regeneration by activating Yap through Src following cardiac injury.
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