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March 25, 2003Annual Review of Immunology

NaturallyArisingCD4+RegulatoryT Cells forImmunologicSelf-Tolerance andNegativeControl ofImmuneResponses

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Authors

Shimon Sakaguchi
Shimon SakaguchiScripps Research Institute

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Shimon Sakaguchi (2003) studied this question.

synapsesocial.com/papers/69d8cd7b33ca018b39ae413dhttps://doi.org/10.1146/annurev.immunol.21.120601.141122
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells1998 · 857 citations
  2. 2Regulatory T Cells in the Control of Autoimmunity: the Essential Role of  Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes1999 · 256 citations
  3. 3Self-Tolerance Checkpoints in B Lymphocyte Development1995 · 333 citations
  4. 4CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activitiesin vitro1998 · 194 citations
  5. 5Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation2000 · 284 citations