What question did this study set out to answer?

To evaluate differences in injection site pain perception between citrate-free and citrate-containing subcutaneous biologic formulations in adult patients.

August 30, 2022Current Rheumatology ReviewsOpen Access

A Systematic Literature Review of Injection Site Pain Perception in AdultPatients Treated with Citrate-Free and Citrate-Containing Biologic Agents

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Authors

SJSophia JunkerSyneos Health (Germany)OEOliver EbertTechnical University of Munich RBR. BartschAmgen (Germany)

Discussion

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Implication

Systematic review finds lower injection site pain with citrate-free biologics in adults, suggesting formulation excipients alter patient comfort.

Key Points

To evaluate differences in injection site pain perception between citrate-free and citrate-containing subcutaneous biologic formulations in adult patients.
Conducted a systematic literature review analyzing studies reporting injection site pain and injection site reactions associated with subcutaneous biologic agents.
Assessed pain perception outcomes across studies comparing citrate-free formulations against citrate-containing formulations.
Subcutaneous administration of citrate-free biologic formulations was qualitatively associated with reduced injection site pain perception compared with citrate-containing formulations.
Excipient compositions were rarely documented in published clinical studies, and pain outcomes remained subject to multiple unmeasured confounding factors.

Cite This Study

Junker et al. (2022) studied this question.

synapsesocial.com/papers/69d8d19f2c39562886ae2e59 https://doi.org/10.2174/1573397118666220829123713

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Implication

Systematic review finds lower injection site pain with citrate-free biologics in adults, suggesting formulation excipients alter patient comfort.

A Systematic Literature Review of Injection Site Pain Perception in AdultPatients Treated with Citrate-Free and Citrate-Containing Biologic Agents

Discussion

Member takes

Implication

Key Points

Cite This Study

A Systematic Literature Review of Injection Site Pain Perception in AdultPatients Treated with Citrate-Free and Citrate-Containing Biologic Agents

Discussion

Member takes

Implication

Key Points

Cite This Study

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