Narrative review outlines advances in transition-metal-catalyzed asymmetric hydroalkynylation of alkenes, highlighting iridium-catalyzed functionalization of enamides.
Catalytic asymmetric hydroalkynylation of unsaturated alkenes provides a straightforward method to construct stereocenters substituted by an alkynyl group. Here we provide an overview of the recent progress of catalytic asymmetric hydroalkynylation reactions. Our recent development of an iridium-catalyzed enantioselective hydroalkynylation of enamides is also discussed. 1 Introduction 2 Catalytic Asymmetric Hydroalkynylation of Electron-Deficient Alkenes 3 Catalytic Asymmetric Hydroalkynylation of Electron-Neutral Alkenes 4 Catalytic Asymmetric Hydroalkynylation of Electron-Rich Alkenes 5 Conclusion
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Li et al. (2017) studied this question.
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