November 28, 2005Molecular and Cellular BiologyOpen Access

periostin Null Mice Exhibit Dwarfism, Incisor Enamel Defects, and an Early-Onset Periodontal Disease-Like Phenotype

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Structured PICO

Population

periostin-deficient (peri(lacZ)) mice

Intervention

periostin gene knockout (replacement of translation start site and first exon with a lacZ reporter gene) and soft diet

Comparator

wild-type mice (implied) and normal diet

Outcome

developmental and phenotypic changes including survival, growth, skeletal structure, periodontal health, and enamel integritysurrogate

Periostin is critically required for maintaining the integrity of the periodontal ligament in response to mechanical stresses.

Authors

HRHéctor F. RíosEmory Healthcare SKShrinagesh V. KoushikAugusta University HWHaiyan WangQingdao University

Discussion

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Implication

No immediate clinical implications from murine periostin deficiency; leaves open translational validation in human periodontal or skeletal stress responses.

Cite This Study

Ríos et al. (2005) studied this question.

synapsesocial.com/papers/69d8f2a01ab91f1400bedad7 https://doi.org/10.1128/mcb.25.24.11131-11144.2005

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Implication

No immediate clinical implications from murine periostin deficiency; leaves open translational validation in human periodontal or skeletal stress responses.