Reduction of clinical safety margins in proton therapy enabled by the clinical implementation of dual-energy CT for direct stopping-power prediction

Key Points

• This research aims to improve the accuracy of range predictions in proton therapy treatment planning using dual-energy CT.
• Implemented patient-specific stopping-power prediction using dual-energy CT
• Achieved a reduction of range prediction uncertainty to a 2% level
• Range prediction accuracy improved significantly, with a reduction in uncertainty to 2% level
• Clinical implementation of DECT resulted in effective stopping-power prediction