Key result
Cardiac Raptor ablation blocks adaptive hypertrophy and triggers heart failure in mice.
Why the study?
The essential function of mTORC1 in the heart under physiological and pathological conditions is important to understand disease states affecting insulin/IGF signaling such as diabetes and heart failure.
mTORC1 has an essential function in the heart under physiological and pathological conditions, with its ablation leading to heart failure in mice.
Raptor ablation causes HF in mice; leaves open mTORC1 targeting for human cardiac hypertrophy.
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Shende et al. (2011) studied this question. Cardiac Raptor ablation in mice impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure, highlighting the essential function of mTORC1 in the heart.
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