Key result
Rapamycin selectively inhibited Angiotensin II-induced p70S6K activation (IC50 0.14 ng/mL) and overall protein synthesis in cardiac myocytes, without affecting specific hypertrophic gene expression.
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No immediate clinical implications; leaves open whether selective p70S6K inhibition modulates myocyte growth in vivo.
Sadoshima et al. (1995) studied Cardiac hypertrophy. Rapamycin vs. Angiotensin II alone was evaluated on p70S6K activation and protein synthesis. Rapamycin selectively inhibited Angiotensin II-induced p70S6K activation (IC50 0.14 ng/mL) and overall protein synthesis in cardiac myocytes, without affecting specific hypertrophic gene expression.
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