Population
human coronary artery smooth muscle cells (cSMCs)
Design
Preclinical
Authors
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May guide targeted studies of PI3-K/mTOR blockade in vascular remodeling; leaves open translation from this animal cell model to clinical disease.
ANG II induces vascular smooth muscle cell growth and protein synthesis through the PI3-K/mTOR signaling pathway, highlighting a molecular mechanism for vascular wall thickening.
Hafizi et al. (2004) studied this question.
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