Key result
Rapamycin selectively inhibited the activation of p70S6K by Angiotensin II and potently inhibited AII-stimulated protein synthesis, indicating p70S6K plays a critical role in vascular SMC hypertrophy.
p70S6K plays a critical role in the signaling pathways by which Angiotensin II induces hypertrophy of vascular smooth muscle cells.
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p70S6K inhibition may limit Ang II-driven vascular hypertrophy; leaves open clinical translation from animal data.
Giasson et al. (1995) studied Cellular hypertrophy in cultured vascular smooth muscle cells. Angiotensin II, Losartan, Rapamycin was evaluated on Phosphotransferase activity of p70S6K and protein synthesis. Rapamycin selectively inhibited the activation of p70S6K by Angiotensin II and potently inhibited AII-stimulated protein synthesis, indicating p70S6K plays a critical role in vascular SMC hypertrophy.
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