Why the study?
Does up-regulating cardiac myosin light chain kinase with neuregulin improve cardiac function in rats with myocardial infarction?
Does up-regulating cardiac myosin light chain kinase with neuregulin improve cardiac function in rats with myocardial infarction?
Up-regulation of cMLCK via rhNRG-1 improves cardiac function in a rat model of myocardial infarction.
Answers are grounded in this paper and cite their sources.
cMLCK up-regulation improves rat post-MI function; extends neuregulin mechanisms but leaves open human translation.
Our results suggest that cMLCK is a downstream effector of rhNRG-1 involved in rhNRG-1-induced cardiac function improvement, and that myocardial cMLCK up-regulation can improve cardiac function in rats with MI.
No takes yet. Share an insight, caveat, or question.
Gu et al. (2010) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: