Key result
Cardiac MLCK is a newly identified kinase specifically expressed in the heart that regulates MLC2 phosphorylation, sarcomere organization, and cardiomyocyte contraction.
The identification of a novel cardiac-specific myosin light chain kinase provides new insights into the molecular regulation of cardiomyocyte contraction and sarcomere organization.
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Hypothesis-generating in animal models; leaves open cardiac MLCK as a therapeutic target in human disease.
Chan et al. (2008) studied this question. Overexpression and knockdown of cardiac MLCK was evaluated on MLC2 phosphorylation, sarcomere organization, and cardiomyocyte contraction. Cardiac MLCK is a newly identified kinase specifically expressed in the heart that regulates MLC2 phosphorylation, sarcomere organization, and cardiomyocyte contraction.
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