Key result
Cardiac MLCK is a newly identified kinase specifically expressed in the heart that regulates MLC2 phosphorylation, sarcomere organization, and cardiomyocyte contraction.
Population
Cultured neonatal cardiomyocytes and mammalian heart tissue
Design
Preclinical
Authors
Loading...
Hypothesis-generating in animal models; leaves open cardiac MLCK as a therapeutic target in human disease.
The identification of a novel cardiac-specific myosin light chain kinase provides new insights into the molecular regulation of cardiomyocyte contraction and sarcomere organization.
Chan et al. (2008) studied this question. Overexpression and knockdown of cardiac MLCK was evaluated on MLC2 phosphorylation, sarcomere organization, and cardiomyocyte contraction. Cardiac MLCK is a newly identified kinase specifically expressed in the heart that regulates MLC2 phosphorylation, sarcomere organization, and cardiomyocyte contraction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: