Why the study?
Does enhanced phosphorylation of the P-light chain by MLCK increase calcium sensitivity in chemically skinned pig ventricular fibres?
Population
Chemically skinned ventricular fibre bundles of the pig
Comparison
Enhanced phosphorylation level of the P-light… vs Baseline state (absence of MLCK)
Design
Preclinical
Authors
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May modulate ventricular contractility via Ca2+ sensitization; leaves open translation to human physiology or therapeutic targeting.
Does enhanced phosphorylation of the P-light chain by MLCK increase calcium sensitivity in chemically skinned pig ventricular fibres?
Enhanced phosphorylation of the P-light chain by MLCK reversibly increases calcium sensitivity in pig ventricular fibres, suggesting a role in regulating cardiac contractility.
Morano et al. (1985) studied this question.
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