What question did this study set out to answer?

To determine whether activating protein kinase A (PKA) can eliminate mesenchymal tumor-initiating cells by driving them into an epithelial differentiation state.

March 3, 2016Science

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

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Authors

DPDiwakar R. PattabiramanBoston Biomedical (United States)BBBrian BierieAbbVie (United States)KKKatharina I KoberGerman Cancer Research Center

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Implication

Preclinical study reveals that PKA activation forces mesenchymal-to-epithelial transition in human mammary cells, indicating a potential differentiation therapy against tumor-initiating cells.

Key Points

To determine whether activating protein kinase A (PKA) can eliminate mesenchymal tumor-initiating cells by driving them into an epithelial differentiation state.
Elevated intracellular levels of adenosine 3',5'-monophosphate (cAMP) to stimulate protein kinase A (PKA) signaling.
Evaluated phenotypic transitions, epigenetic reprogramming, and tumor-initiating capacity in mesenchymal human mammary epithelial cells.
PKA activation triggered a mesenchymal-to-epithelial transition (MET) in mesenchymal human mammary epithelial cells.
PKA-induced signaling recruited the histone demethylase PHF2 to mediate epigenetic reprogramming, prompting differentiation and irreversible loss of tumor-initiating ability.

Cite This Study

Pattabiraman et al. (2016) studied this question.

synapsesocial.com/papers/69d8fa208c03fbaff8bf02c5 https://doi.org/10.1126/science.aad3680

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Implication

Preclinical study reveals that PKA activation forces mesenchymal-to-epithelial transition in human mammary cells, indicating a potential differentiation therapy against tumor-initiating cells.

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

Discussion

Member takes

Implication

Key Points

Cite This Study

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

Discussion

Member takes

Implication

Key Points

Cite This Study

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