What question did this study set out to answer?

To investigate the brain structural correlates and cognitive mechanisms that drive the age-related reduction in motor adaptation across the adult lifespan.

February 20, 2020Neurobiology of AgingOpen Access

Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory

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To investigate the brain structural correlates and cognitive mechanisms that drive the age-related reduction in motor adaptation across the adult lifespan.
Assessed motor adaptation in a population-based cohort (N=322, aged 18–89 years) using a visuomotor learning task.
Acquired structural magnetic resonance imaging (MRI) scans to quantify regional brain volumes in the cerebellum, striatum, medial temporal lobe, and prefrontal and sensorimotor cortices.
Administered cognitive batteries measuring declarative long-term memory and visual short-term memory to evaluate explicit memory contributions.
Reduced motor adaptation with advancing age was associated with smaller volumes in the striatum, prefrontal cortex, and sensorimotor cortex, but was not associated with cerebellar volume.
Medial temporal lobe volume, including the hippocampus, and declarative long-term memory performance showed significant positive interactions with age, becoming stronger determinants of motor adaptation in older adults.
Visual short-term memory maintained a stable positive relationship with motor adaptation regardless of age, indicating that deficits in explicit long-term memory systems drive motor adaptation declines.

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Implication

Population-based cohort study demonstrates that explicit memory decline drives reduced motor adaptation in aging adults, highlighting the preservation of cerebellar learning across the lifespan.

Cite This Study

Wolpe et al. (2020) studied this question.

synapsesocial.com/papers/69d8ff774332c00a00ae29db https://doi.org/10.1016/j.neurobiolaging.2020.02.016

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Implication

Population-based cohort study demonstrates that explicit memory decline drives reduced motor adaptation in aging adults, highlighting the preservation of cerebellar learning across the lifespan.

Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory

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Discussion

Implication

Cite This Study

Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory

Key Points

Discussion

Implication

Cite This Study

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