Heparin and heparin proteoglycan-mimetics activate platelets via the PEAR1 receptor and downstream PI3Kβ signaling, providing mechanistic insights relevant to cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for PEAR1-targeted antithrombotics; leaves open human translation and clinical relevance.
Our findings reveal that PEAR1 is a receptor for heparin and HPGM and that PI3Kβ is a key signaling molecule downstream of PEAR1 in platelets. These findings may have important implications for our understanding of the role of PEAR1 in cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Kardeby et al. (2023) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: