What question did this study set out to answer?

To introduce the 2016 update of g:Profiler, an established bioinformatics web server designed for functional enrichment analysis and identifier translation of gene lists.

April 20, 2016Nucleic Acids ResearchOpen Access

g:Profiler—a web server for functional interpretation of gene lists (2016 update)

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Authors

JRJüri Reimand TAT. V. Arak PAPriit Adler

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Overview

Web server update reveals expanded functional enrichment and gene identifier translation across 213 species, highlighting improved biological interpretation of genetic data.

Key Points

To introduce the 2016 update of g:Profiler, an established bioinformatics web server designed for functional enrichment analysis and identifier translation of gene lists.
Synchronized gene, Gene Ontology, and pathway annotations quarterly with the Ensembl database across 213 species, including vertebrates, plants, insects, and fungi.
Integrated additional functional datasets covering transcription factor binding site predictions, Mendelian disease annotations, protein expression and complexes, and human genetic polymorphisms.
Expanded access options beyond the web interface to include an R package, a Python interface, and a BioJS component for programmatic pipeline integration.
Expanded functional profiling support to 213 organisms while maintaining automated quarterly data updates aligned with Ensembl.
Added multi-source functional annotations enabling simultaneous query of disease traits, regulatory elements, and protein complex mappings from flat or ranked gene lists.

Cite This Study

Reimand et al. (2016) studied this question.

synapsesocial.com/papers/69d903864332c00a00ae2c91 https://doi.org/10.1093/nar/gkw199

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April 20, 2016Nucleic Acids ResearchOpen Access

g:Profiler—a web server for functional interpretation of gene lists (2016 update)

View Full Paper

Ask AI

Bookmark

Authors

JRJüri Reimand TAT. V. Arak PAPriit Adler

Discussion

Member takes

Overview

Web server update reveals expanded functional enrichment and gene identifier translation across 213 species, highlighting improved biological interpretation of genetic data.

Key Points

To introduce the 2016 update of g:Profiler, an established bioinformatics web server designed for functional enrichment analysis and identifier translation of gene lists.
Synchronized gene, Gene Ontology, and pathway annotations quarterly with the Ensembl database across 213 species, including vertebrates, plants, insects, and fungi.
Integrated additional functional datasets covering transcription factor binding site predictions, Mendelian disease annotations, protein expression and complexes, and human genetic polymorphisms.
Expanded access options beyond the web interface to include an R package, a Python interface, and a BioJS component for programmatic pipeline integration.
Expanded functional profiling support to 213 organisms while maintaining automated quarterly data updates aligned with Ensembl.
Added multi-source functional annotations enabling simultaneous query of disease traits, regulatory elements, and protein complex mappings from flat or ranked gene lists.

Cite This Study

Reimand et al. (2016) studied this question.

synapsesocial.com/papers/69d903864332c00a00ae2c91 https://doi.org/10.1093/nar/gkw199

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