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November 1, 2011SHILAP Revista de lepidopterología569 citationsOpen Access

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

TKTuomas O. KilpeläinenLQLu QiSBSøren Brage

Key Points

  • To determine whether physical activity attenuates the effect of FTO gene variants on the risk of obesity.
  • Meta-analysis pooling data from 218,166 adults and 19,268 children.
  • Assessed interaction effects between physical activity levels and FTO risk alleles on obesity odds.
  • Physical activity attenuated the association between the FTO risk allele and obesity odds by 27% in physically active adults.

Abstract

The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.

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Cite This Study

Kilpeläinen et al. (2011) studied this question.

synapsesocial.com/papers/69d9084df544bba627bee103https://doi.org/10.1371/journal.pmed.1001116
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