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May 16, 2026Nutrition Research ReviewsOpen Access

Genetic Influences on Obesity: The Role of FTO and the Promise of Precision Nutrition in Personalized Weight Management

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Authors

WSW.M. Bhagya SewwandiUniversity of ColomboMDMaduka de Lanerolle DiasUniversity of Colombo

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Implication

Narrative review examines the role of FTO gene variants in obesity, indicating the potential of personalized dietary strategies.

Key Points

  • This review explores how FTO gene variants influence obesity and evaluates evidence for gene-diet interactions in weight management.
  • Synthesized data from mechanistic studies, observational cohorts, randomized controlled trials, and meta-analyses.
  • Assessed dietary interventions, including macronutrient composition and Mediterranean-style diets, in context of FTO risk alleles.
  • Examined genotype-specific obesity risk modification and intervention effectiveness.
  • Mechanistic and observational evidence supports the role of FTO variants in appetite regulation and energy intake.
  • Intervention studies show that responses to dietary changes vary modestly based on genetic profiles.
  • Current findings advocate for precision nutrition as a complementary approach rather than a definitive solution for obesity management.

Cite This Study

Sewwandi et al. (2026) studied this question.

synapsesocial.com/papers/6a080a9fa487c87a6a40c942https://doi.org/10.1017/s0954422426100432
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of Fat Mass and Obesity-Associated (FTO) Gene Polymorphism with Obesity Risk: A Systematic Review Protocol2025 · 1 citations
  2. 2Impact of fat mass and obesity-associated (FTO) gene variants on adult obesity and overweight: a comprehensive meta-analysis2026
  3. 3FTO as an epigenetic regulator in metabolic and inflammatory diseases2025 · 3 citations
  4. 4Association of Genetic Polymorphisms in the Human FTO Gene and Obesity: Systematic Review and Meta-Analysis2025
  5. 5THE INFLUENCE OF FTO AND LEP GENE VARIANTS ON OBESITY STATUS IN CHILDREN: A SYSTEMATIC REVIEW2025