The Methylation Effect in Medicinal Chemistry

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTThe Methylation Effect in Medicinal ChemistryEliezer J. Barreiro*†‡§, Arthur E. Kümmerle†§, and Carlos A. M. Fraga†‡§View Author Information† Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitária, CP 68.006, 21941-902 Rio de Janeiro, RJ, Brazil‡ Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, Brazil§ Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, BrazilPhone: 55-21-25626644. E-mail: email protected. Website: http://www.farmacia.ufrj.br/lassbio.Cite this: Chem. Rev. 2011, 111, 9, 5215–5246Publication Date (Web):June 1, 2011Publication History Received18 February 2011Published online1 June 2011Published inissue 14 September 2011https://pubs.acs.org/doi/10.1021/cr200060ghttps://doi.org/10.1021/cr200060greview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views18979Altmetric-Citations659LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Inhibitors,Pharmaceuticals,Reaction products,Receptors Get e-Alerts