What question did this study set out to answer?

Investigate how modulating nanoparticle avidity to the transferrin receptor influences receptor-mediated transcytosis across the blood–brain barrier into the brain parenchyma.

May 6, 2013Proceedings of the National Academy of SciencesOpen Access

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

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Authors

DWDevin T. WileyCalifornia Institute of Technology PWPaul WebsterUniversity of Southern California AGAaron GaleCalifornia Institute of Technology

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Implication

Animal study demonstrates that tuning transferrin receptor avidity optimizes nanoparticle uptake into brain tissue in mice, highlighting a pathway for targeted central nervous system therapeutics.

Key Points

Investigate how modulating nanoparticle avidity to the transferrin receptor influences receptor-mediated transcytosis across the blood–brain barrier into the brain parenchyma.
Systemically administered transferrin-conjugated gold nanoparticles of 45 nm and 80 nm diameters with varying surface transferrin densities in mice.
Visualized nanoparticle passage across the blood–brain barrier and accumulation in brain parenchyma using silver enhancement light microscopy and transmission electron microscopy.
Nanoparticles of both 45 nm and 80 nm crossed into the brain parenchyma, with parenchymal uptake depending on transferrin content and receptor avidity.
Nanoparticles with high transferrin avidity remained trapped on brain endothelial cells, whereas lower avidity permitted both luminal receptor binding and detachment into the brain.

Cite This Study

Wiley et al. (2013) studied this question.

synapsesocial.com/papers/69d91a1d7fca1f84ab684224 https://doi.org/10.1073/pnas.1307152110

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Implication

Animal study demonstrates that tuning transferrin receptor avidity optimizes nanoparticle uptake into brain tissue in mice, highlighting a pathway for targeted central nervous system therapeutics.

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

Discussion

Member takes

Implication

Key Points

Cite This Study

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

Discussion

Member takes

Implication

Key Points

Cite This Study

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