AMPK alterations in cardiac physiology and pathology: enemy or ally?
Why the study?
Does AMPK activation benefit or harm the ischaemic and hypertrophied heart?
Population
Ischaemic and hypertrophied heart models
Design
Review
Authors
Discussion
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Member takes
Implication
Complicates AMPK as therapeutic target in ischaemic and hypertrophied hearts; leaves open net benefit versus harm pending resolution of dual effects.
Structured PICO
Does AMPK activation benefit or harm the ischaemic and hypertrophied heart?
P
Population
Ischaemic and hypertrophied heart models
I
Intervention
AMPK activation or inhibition
The review highlights the dual and controversial role of AMPK in cardiac ischaemia and hypertrophy, complicating its potential as a therapeutic target.
Cite This Study
Dyck et al. (2006) studied this question.