What does this research mean for the field?

Hypertrophied hearts exhibit increased susceptibility to ischemic injury but decreased susceptibility to hypoxic injury compared to normal hearts, likely due to a greater capacity for glycolytic metabolism that leads to rapid accumulation of harmful by-products during ischemia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1990Circulation Research

Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts.

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Population

Isolated hearts from rats with aortic arch banding at 23 days of age and sham-operated rats

Comparison

Global ischemia until peak ischemic contracture… vs Sham-operated normal rat hearts

Design

Preclinical

Authors

PAPeter G. AndersonUniversity of Alabama at Birmingham MAM. F. AllardUniversity of British Columbia GTGail D. ThomasPenn State Milton S. Hershey Medical Center

Discussion

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Implication

Hypertrophied hearts' opposing ischemia versus hypoxia responses should not alter clinical management; leaves open glycolytic adaptation mechanisms for targeted study.

Structured PICO

Population

Isolated hearts from rats with aortic arch banding at 23 days of age (hypertrophied) and sham-operated rats (8 weeks postoperative)

Intervention

Global ischemia until peak ischemic contracture followed by 30 minutes reperfusion, or 15 minutes glucose-free hypoxic perfusion followed by 20 minutes oxygenated perfusion

Comparator

Sham-operated normal rat hearts

Outcome

Degree of ischemic and hypoxic injury (measured by postischemic recovery of left ventricular pressure, lactate levels, ischemic contracture, and lactate dehydrogenase release)surrogate

Hypertrophied rat hearts show increased susceptibility to ischemic injury but decreased susceptibility to hypoxic injury, likely due to a greater potential for glycolytic metabolism.

Cite This Study

Anderson et al. (1990) studied this question.

synapsesocial.com/papers/6a1b7f3c39ea7417dc42e829 https://doi.org/10.1161/01.res.67.4.948

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Implication

Hypertrophied hearts' opposing ischemia versus hypoxia responses should not alter clinical management; leaves open glycolytic adaptation mechanisms for targeted study.

Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider