Why the study?
Does preischemic glycogen reduction or glycolytic inhibition improve postischemic recovery of hypertrophied rat hearts?
Population
Isolated hearts from aortic-banded (Band) and sham-operated (Sham) rats (8 weeks postop)
Comparison
Preischemic glycogen reduction or glycolytic… vs Untreated controls
Design
Preclinical
Follow-up
30 min normoxic reperfusion
Authors
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May support metabolic modulation in hypertrophied hearts; leaves open translation to human ischemia-reperfusion injury.
Does preischemic glycogen reduction or glycolytic inhibition improve postischemic recovery of hypertrophied rat hearts?
Preischemic glycogen reduction or glycolytic inhibition improves postischemic recovery of left ventricular function in hypertrophied rat hearts.
Allard et al. (1994) studied this question.
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