Key result
Lactate addition improves functional recovery in isolated post-ischemic rat hearts, correlating with preserved glycogen content.
Why the study?
Functional recovery after ischemia and reperfusion in isolated working rat hearts perfused with glucose was examined in relation to metabolic variables including ATP, glycogen, and glucose 6-phosphate levels.
Population
Isolated working rat hearts perfused with glucose (11 mM)
Comparison
Feeding vs fasting in vivo; addition of L-lactate, dl-beta-hydroxybutyrate, glucagon, and anoxic perfusion before ischemia
Design
Preclinical experimental study
Authors
Loading...
May inform substrate effects on rat heart recovery but should not change practice; leaves open translation to clinical ischemia-reperfusion.
In isolated rat hearts, postischemic functional recovery is closely linked to glycogen resynthesis and oxidative metabolism, highlighting the importance of citric acid cycle anaplerosis.
Goodwin et al. (1994) studied Ischemia and reperfusion. Various metabolic interventions (feeding/fasting, L-lactate, dl-beta-hydroxybutyrate, glucagon, anoxic perfusion) was evaluated on Functional recovery (percentage of preischemic power). Functional recovery of isolated working rat hearts following ischemia and reperfusion correlated with postischemic glycogen content and was improved by the addition of lactate.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: