In a murine model of Type 2 diabetes, enhanced superoxide production impairs NO-mediated flow- and agonist-induced dilations of coronary arterioles, suggesting a mechanism for microvascular dysfunction and ischemic heart disease.
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Implicates superoxide in diabetic coronary microvascular dysfunction; leaves open whether antioxidant strategies improve human outcomes.
Bagi et al. (2003) studied this question.
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