What question did this study set out to answer?

To determine how interpersonal relationships and cohabitation shape the transmission and genetic makeup of the human gut and oral microbiomes.

January 18, 2023NatureOpen Access

The person-to-person transmission landscape of the gut and oral microbiomes

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Authors

MVMireia Valles‐ColomerUniversitat Pompeu Fabra ABAitor Blanco‐MíguezUniversity of Trento PMPaolo ManghiFondazione Edmund Mach

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Implication

Metagenomic analysis reveals extensive person-to-person bacterial strain sharing in cohabiting individuals, highlighting social transmission in non-communicable diseases.

Key Points

To determine how interpersonal relationships and cohabitation shape the transmission and genetic makeup of the human gut and oral microbiomes.
Conducted computational strain-level profiling across more than 9,700 human metagenomes.
Assessed mother-to-infant, intra-household, and intra-population transmission patterns, tracking strain sharing and out-of-host bacterial survival traits.
Mother-to-infant gut microbiome transmission demonstrated a strain-sharing rate of around 50% during infancy and remained detectable at older ages.
Cohabiting individuals exhibited median strain-sharing rates of 12% for gut microbiomes and 32% for oral microbiomes, with duration of cohabitation affecting sharing more than genetics or age.
Detected more than 10 million strain-sharing instances across transmission modes, with strain-level profiles recapitulating host population structures better than species-level profiles.

Cite This Study

Valles‐Colomer et al. (2023) studied this question.

synapsesocial.com/papers/69d946edf20ef26330684692 https://doi.org/10.1038/s41586-022-05620-1

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Implication

Metagenomic analysis reveals extensive person-to-person bacterial strain sharing in cohabiting individuals, highlighting social transmission in non-communicable diseases.

The person-to-person transmission landscape of the gut and oral microbiomes

Discussion

Member takes

Implication

Key Points

Cite This Study

The person-to-person transmission landscape of the gut and oral microbiomes

Discussion

Member takes

Implication

Key Points

Cite This Study

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