Nuclear plakoglobin drives the differentiation of c-Kit+ cardiac progenitor cells into adipocytes, providing a mechanistic explanation for fibrofatty replacement in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC).
Nuclear PG provokes adipogenesis in c-Kit+ CPCs by repressing the canonical Wnt signaling and inducing a proadipogenic gene expression. The findings suggest that adipocytes in ARVC, at least in part, originate from c-Kit+ CPCs.
Lombardi et al. (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: