Nuclear plakoglobin drives the differentiation of c-Kit+ cardiac progenitor cells into adipocytes, providing a mechanistic explanation for fibrofatty replacement in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC).
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Should not yet change ARVC practice; hypothesis-generating for nuclear PG targeting in human CPCs.
Nuclear PG provokes adipogenesis in c-Kit+ CPCs by repressing the canonical Wnt signaling and inducing a proadipogenic gene expression. The findings suggest that adipocytes in ARVC, at least in part, originate from c-Kit+ CPCs.
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Lombardi et al. (2011) studied this question.
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